TP53 and renal carcinoma: Debata et al. (2013) reported that the sunitinib-curcumin combination was effective in restoring the tumor suppressor activity of the RB gene in renal cancer cells. Furthermore, Su, Wang & Chiu (2010) reported that curcumin significantly enhanced p53 or markedly inhibited the RB pathway by suppressing RB phosphorylation in the signaling pathways of glioblastoma (Su, Wang & Chiu, 2010).