Regarding HCC cell levels, TGFB1 was a potent growth inhibitor and induces apoptosis in these cells, so it is regarded as a tumor-suppressive cytokine (Senturk et al., 2010).Therefore, further studies are needed to validate and establish the specific molecular mechanisms by which curcumin regulates HCC cells. The gene discussed is TGFB1; the disease is neoplasm.