IRF5 and hepatocellular carcinoma: As listed in Table 2, HSPA4 significantly positively correlated with B cell biomarkers (CD19, CD20, and CD38), CD8+ T cell biomarkers (CD8A), other T cell subsets (Tfh, Th1, Th2, Th9, Th17, Th22, and Treg), M1 macrophage biomarkers (IRF5 and PTGS2), M2 macrophage biomarkers (CD115), TAM biomarkers (PDCD1LG2, CD80, CD40, and TLR7), natural killer cell biomarkers (CD7 and XCL1), neutrophil biomarkers (ITGAM and FUT4), and dendritic cell biomarkers (CD1C and ITGAX) in HCC.