ADCY1 and acute respiratory distress syndrome: Consistent with the previous GO and KEGG analysis using Metascape, GSEA highlighted biological programs of adenylate cyclase inhibiting G protein coupled receptor signaling pathway, macrophage migration, ERK1 and ERK2 cascade, cytokine-cytokine receptor interaction, PPAR signaling pathway, complement and coagulation cascades and JAK-STAT signaling pathway as the key transcriptional changes in activated AMs of ARDS.