AKT1 and osteoarthritis: In the KEGG signaling pathway, we analyzed that DEGs were significantly enriched in FoxO, JAK-STAT, PI3K-Akt, and TGF-beta signaling pathways, etc. The study by Ma et al. analyzed the regulatory role of the FoxO signaling pathway in bone cell function and confirmed that FoxO dysfunction in bone cells would cause osteoarthritis, osteoporosis, and other bone diseases [21].