SLC22A12 and hyperuricemia: Another flavonoid, baicalein (compound 4) (Figure 2), was shown by Chen et al. [41] to noncompetitively inhibit URAT1 in a dose-dependent manner with IC50 of 31.6 μM. In vivo animal studies have demonstrated that 200 mg/kg baicalein can significantly lower urate levels in PO-induced hyperuricemia mice by elevating urate excretion.