Some studies have shown that COX-2 is involved in the pathogenesis of migraine, and the presence of aura has no effect on the level of serum COX-2, and some studies have suggested that exercise may improve the symptoms of vestibular migraine patients by inhibiting the COX-2 proinflammatory pathway and reducing the levels of TNF-α, IL-2, IL-6, and other proinflammatory factors [13]. Here, TNF is linked to migraine disorder.