It involves PI3K-Akt signal pathway, AGE-RAGE signal pathway, MAPK signal pathway, HIF-1 signal pathway, IL-17 signal pathway in diabetic complications, and signal pathways closely related to fluid shear stress and atherosclerosis, endocrine resistance, endometrial cancer, prostate cancer, etc., which mainly play an important role in inhibiting inflammatory reaction, hormone, and endocrine regulation. This evidence concerns the gene RENBP and Familial prostate cancer.