Given the above, and following the model of CAH caused by loss of function mutation in CYP11B1 gene, we propose that altered function of P-45011β, or its lower production, leads to the enhanced production of 11-deoxycortisol and 11-deoxycorticosterone, and hence, results in differences in skeletal maturation of pre-pubertal children. The gene discussed is CYP11B1; the disease is congenital adrenal hyperplasia.