Not only TGF-β but also interleukin (IL)-8, IL-6, and tumor necrosis factor-α are increased in the AH in POAG, and Kaeslin et al. found that several inflammatory processes are involved in the upregulated signaling pathways in POAG by GO analysis based on a proteomic analysis of the AH19–21. This evidence concerns the gene TNF and open-angle glaucoma.