In the gene signal network analysis, Acat1, Acadvl, Acaa2, Hadhb, Acss1, Oxct1, Hadha, Hadh, Acaca, and Cpt1b may play key roles in the development and progression of muscle atrophy after SCI because they had the highest betweenness values (higher betweenness indicates more connections with a gene, suggesting that the gene may be more important). The gene discussed is ACAT1; the disease is Atrophy.