On the other hand, the strong linkage disequilibrium25 of the SNPs in COL11A2 and HLA-DP and the risk of GVHD related to HLA-DPB1 mismatching in unrelated HSCT26 may provide an explanation for the association of rs986522 with GVHD. The gene discussed is COL11A2; the disease is graft versus host disease.