In men with low PSA levels, it was confirmed that the performing MRI-TBx was significantly correlated with the detection of both PCa [odds ratio (OR) 1.895; 95% confidence interval (CI) 1.355‒2.651; P < 0.001] and csPCa (OR 2.872; 95% CI 1.996‒4.132; P < 0.001). The gene discussed is KLK3; the disease is posterior cortical atrophy.