In addition, MRI-TBx showed a significant correlation in the detection of both PCa (OR 1.895; 95% CI 1.355‒2.651; P < 0.001) and csPCa (OR 2.872; 95% CI 1.996‒4.132; P < 0.001) in men with low PSA levels. This evidence concerns the gene KLK3 and posterior cortical atrophy.