SNCA and Parkinson disease: There was a significant correlation between L1CAM exosomal lnc-POU3F3 levels and PD severity, including motor/cognitive impairment.519 Four lncRNAs (SNCA-AS1, MAPT AS1, AK127687, and AX747125) were detected in exosomes from human cerebrospinal fluid, providing preliminary evidence that these lncRNAs may be of potential use as a diagnostic tool for PD.520 However, further research is needed to elucidate their possible role in PD.