PKM and colorectal carcinoma: Shang et al. determined that exosome-encapsulated circPACRGL from CRC patients stimulates tumor cell proliferation, migration, invasion, and metastasis, as well as neutrophil differentiation.278 Moreover, exosomal circFMN2 mediates cell proliferation and migration,279 while exosomal circIFT80 is implicated in promoting CRC development.280 Exosomal has-circ-0005963 and circ-133 regulate the process of CRC by targeting miR-122/M2 isoform of pyruvate kinase (PKM2) axis281 and miR-133a/GEF-H1/RhoA axis,282 respectively.