OXR1 and Parkinson disease: MiR-195, miR-24, and miR-331-5p were upregulated whereas miR-19b and miR-505 were downregulated in circulating exosomes of patients with PD.513,514 Moreover, the increase of miR-137 was observed in the plasma of PD patients.515,516 Downregulation of exosomal miR-137 can upregulate oxidative resistance 1 (OXR1) in PD mice model, thereby generating a neuroprotective effect.517