A549 NSCLC cells-derived exosomal miR-208a inhibits NSCLC cell proliferation by targeting p21 thus activating the AKT/mTOR pathway.145 In addition, exosomal miR-512 suppresses cell proliferation by targeting TEA domain family member 4 (TEAD4).146. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.