Hypoxic lung cancer cells promote angiogenesis by repressing the tight junction protein ZO-1 through exosomal miR-23a.150 Exosomal miR-126 secreted by NSCLC cells can trigger angiogenesis and accelerate lung cancer progression.144 In addition, miR-210 packaged in exosomes from tumor cells stimulates angiogenesis.151. Here, TJP1 is linked to lung carcinoma.