It has been found that miR-34a promotes amyloid processing of APP, whereas knockdown of miR-34a reduces APP accumulation in brain tissues.486,487 Exosomes secreted by miR-34a-overexpressing neurons can be absorbed by adjacent neurons, resulting in the inhibition of target genes in neural network.488 Overexpression of miR-34a in AD tissues is correlated with simultaneous inhibition of target genes of synaptic plasticity, oxidative phosphorylation, and glycolysis. Here, APP is linked to Alzheimer disease.