LncRNAs profiles in RA serum exosomes were analyzed, and it was found that Hotair, LUST, anti-NOS2a, MEG9, SNHG4, TUG1, and NET1 were upregulated in RA serum exosomes and Hotair expression level was increased by an average of about 4 times in RA exosomes. This evidence concerns the gene HOTAIR and rheumatoid arthritis.