AKT1 and Glucose intolerance: Liver-derived exosomal miR-130a-3p ameliorates glucose intolerance and IR by repressing pleckstrin homology domain leucine-rich repeat protein phosphatases 2 (PHLPP2) thus triggering AKT/Akt substrate of the 160 kDa (AS160)/glucose transporter 4 (GLUT4) axis in adipocytes.355 Expression level of hepatocyte-released exosomal miR-7218-5p in HFD mice is lower compared with that in normal diet mice.