Therefore, exosomal lncRNA-ATB is a promising prognostic biomarker for HCC.208 In addition, expression levels of LINC00161, LINC00635, lncRNA-RP11-583F2.2, lnc-FAM72D-3, lnc-EPC1-4, and lncRNA-HEIH in exosomes are high in HCC patients.212,227–230 On the contrary, SENP3-EIF4A1 and linc-FAM138B are downregulated in plasma exosomes in HCC patients. This evidence concerns the gene HEIH and hepatocellular carcinoma.