SOX2 and neoplasm: Exosomal lncRNAs such as H19, MALAT1, HOTAIR, UCA1, lnc-MMP2-2, GAPLINC, TBILA, AGAP2-AS1, and SOX2-OT play several roles in pathological processes including cell proliferation, migration, invasion, and EMT linked to lung cancer.153 Li et al. reported that GAS5 in exosomes is not only important for cancer development, but a promising biomarker for diagnosis patients with early NSCLC.154 Teng et al. found that exosomal SOX2-OT can be used as an effective noninvasive plasma-based tumor marker for lung squamous cell carcinoma (LSCC).155