MMP2 and liver dysplastic nodule: Furthermore, exosomal circRNA DLGAP4 have been shown to induce mesangial cell proliferation and fibrosis, as well as exacerbating DN in vivo by sponging miR-143 to motivate Erb-b2 receptor tyrosine kinase 3 (ERBB3)/NF-κB/matrix metalloproteinase-2 (MMP-2) axis.373