For instance, BC cells-derived exosomal miR-20a-5p enhances differentiation of osteoclasts by targeting SRCIN1.183 MiR-23b is upregulated in BC cells-derived exosomes and reduces expression of MARCKS, a key regulator of cell cycling and motility.184 Notably, miR-210 from BC cells-derived exosomes can promote angiogenesis.185 On the contrary, miR-16 and miR-100 in exosomes from mesenchymal stem cells (MSCs) reduce secretion of VEGF in tumor cells and inhibit angiogenesis.186,187. This evidence concerns the gene VEGFA and neoplasm.