L1CAM and Parkinson disease: Among them, lnc-MKRN2-42:1 was positively correlated with MDS-UPDRS III score, which is used to evaluate the severity of dyskinesia in PD patients.518 Compared with the control group, the concentrations of lnc-POU3F3 and α-SYN increased in neuro-derived L1CAM exosomes in PD patients.