SMAD7 and osteoporosis: Among the effected changes, miR-885-5p is expression of miR-885-5p is lowered and proven to serve as a negative regulator of BMSCs osteogenic differentiation by suppressing Wnt5 and runt-related transcription factor 2 (Runx2).393 According to Jiang et al., miR-21-bearing exosomes in osteoporosis patients repress osteogenesis by targeting small mothers against decapentaplegic homolog 7 (Smad7).394 Further, a study by Xu et al. reported that exosomal miR-128-3p derived from MSCs in aged rats inhibits osteogenesis and fracture healing through dampening Smad5.390