PVT1 and gastric cancer: Studies report that cancer cell-derived exosomes affect autophagy in recipient cells.104 In addition, exosome regulate drug resistance and tumor microenvironment in an autophagy-dependent manner.105 For instance, exosomal circ-PVT1 promotes cisplatin resistance in gastric cancer cells by inducing cell autophagy and invasion and inhibiting apoptosis.106 Furthermore, gastric cancer cell-derived exosomes trigger autophagy and promote activation of neutrophils, ultimately promoting gastric cancer cell migration.72