Exosomal ciRS-133 stimulates preadipocytes differentiation into brown-like cells by regulating miR-133/ PRDM16 pathway.315 Exosomal circNEK9 promotes proliferation, migration, invasion, and motility of recipient GC cells by modulating miR-409-3p/MAP7 axis.316 Moreover, circ-PVT1 is highly expressed in cisplatin-resistant GC cells-derived exosomes. This evidence concerns the gene PRDM16 and gastric cancer.