SBS2 and SBS13 (AID/APOBEC) were almost exclusively confined to ETV-RUNX1 tumours (QMan–Whitney = 2.3 × 10−33 and QMan–Whitney = 1.1 × 10−36 respectively), whilst SBS7a (UV exposure) was highly enriched in iAMP21 tumours (QMan–Whitney = 5.3 × 10−12) (Supplementary Figs. 16 and 17). Here, AICDA is linked to neoplasm.