To further determine that PI3K/Akt and MAPK/Erk pathways were responsible for MMP1/PAR1 axis-induced proliferation of colon cancer cells, an Erk1/2 inhibitor (SCH772984) and an Akt inhibitor (MK-2206) were applied in the present study. This evidence concerns the gene MAPK3 and malignant colon neoplasm.