Our secondary goal was to identify cell types that activate RIPK3 and MLKL early after CCI and identify potential mechanisms downstream of RIPK3 associated with cognitive impairment, with a focus on interleukin-1 beta (IL-1β) because of its known involvement in postinjury cognitive deficits in cerebral contusion models [18]. The gene discussed is RIPK3; the disease is Cognitive impairment.