TOP1 and neuroblastoma: Thus, we screened CHP-134, IMR-5, BE(2)-M17, and KELLY neuroblastoma cell lines with the combination of CX-5461 and AZD-1390 (ATM inhibitor), AZD-6738 (ATR inhibitor), and SN-38 (the active metabolite of irinotecan; TOP1 inhibitor)44–48.