NFTs and TAU-missorting are associated with neuronal dysfunction, loss of synapses, and neurodegeneration.2 Strong genetic evidence both from the human disease and mouse models put Aβ/APP-processing and TAU in the center of disease causes: all genetic forms of AD are due to mutations in the APP-gene or genes involved in the processing of APP (PSEN1, PSEN2), while mutations in MAPT, the gene coding for the TAU protein, are sufficient to cause related dementia syndromes, i.e., FTD variants like Progressive Supranuclear Palsy or variants of FTLD-TAU. This evidence concerns the gene APP and frontotemporal dementia.