Immune checkpoint protein inhibitor therapy (ICT), such as antibodies against PD-L1 or PD-1, has shown effectiveness against a variety of cancers, including skin cutaneous melanoma (SKCM), non-small cell lung cancer (NSCLC) and breast cancer, with many patients who previously failed a variety of other treatment strategies achieving sustained remission. This evidence concerns the gene CD274 and non-small cell lung carcinoma.