In contrast, among nSMase2−/−, Rab27a−/− and CD73−/− GL-261 tumour-bearing mice, only tumours smaller than 0.2 cm2 were collected after 3 weeks, tumours appeared to stop growing in the following 2 weeks, and the longest survival times were 69, 72 and 148 days, respectively. This evidence concerns the gene NT5E and neoplasm.