In fact, as early as 2011, studies found that CD73+ TDEVs secreted by a variety of cancer cells inhibit the immune activity of T cells in vitro [5]; in addition, high levels of CD73 expression can be detected in GBM and are related to the poor prognosis of GBM [4, 23, 24]. The gene discussed is NT5E; the disease is glioblastoma.