NAC administration included at the stage of developed hyperglycemia did not prevent an increase of Bax and Bcl-2 concentrations or the Bax/Bcl-2 ratio in the mitochondrial fraction of the submandibular glands of rats, as a result of which Bax and Bcl-2 levels and the Bax/Bcl-2 ratio were considerably enhanced compared to the control group (↑37% p = 0.0001, ↑34% p = 0.0017, ↑61 % p = 0.0003, respectively). This evidence concerns the gene BAX and Hyperglycemia.