The results presented herein are innovative and allow us to assess the activity of the main sources of ROS/RNS: respiratory chain enzymes, NOX, and XO as well as the processes accompanied by ROS formation, i.e., inflammation and apoptosis in the salivary glands of rats in whom NAC supplementation was introduced at the stage of HFD-induced hyperglycemia. This evidence concerns the gene XDH and Hyperglycemia.