FOXO3 and Hyperglycemia: As shown in Fig. 4g and h, the protein expression of both FoxO1 and FoxO3a were significantly reduced in H9c2 cells exposed to hyperglycemia (all P < 0.05, HG vs. NC) and were further significantly reduced when the cells were subjected to H/R (all P < 0.05, HG + HR vs. HG), and administration of propofol reverted H/R induced reductions in FoxO1 and FoxO3a expression (all P < 0.05, HG + HR + P25 vs. HG + HR).