FOXO1 and Hyperglycemia: Specific questions remain regarding whether FoxO1 and FoxO3a may mediate the cardioprotective effect of propofol postconditioning (P-PostC) on myocardial I/R injury under hyperglycemia, or whether P-PostC can reduce cellular oxidative stress by regulating the expression of FoxO1 and/or FoxO3a to protect the diabetic heart remains unclear.