WWC1 and Alzheimer disease: In addition, accumulation of K281- and K274-acetylated tau causes hippocampal LTP impairment and memory deficits, which are attributed to the reduction of memory-associated postsynaptic Kidney/BRAin (KIBRA) protein, as well as postsynaptic F-actin remodeling and disruption of AMPAR membrane anchoring, in both AD patient brains and transgenic mice expressing human tau that mimics K281 and K274 acetylation [12] (Fig. 1).