These negative genetic correlations corroborate the epidemiological associations, previous research findings and clinical observations of CRF and PA and body composition [77, 78], lipid profile [79, 80], adipocytokines [81], fasting insulin and insulin resistance [82–86] and leptin [76], T2D [87–89] and CAD [90]. The gene discussed is INS; the disease is type 2 diabetes mellitus.