Genetic variation associated with lower CRF-vo2max was correlated with features of the typical type-2 diabetes (T2D) profile: higher insulin resistance (HOMA-IR: rg=−0.58, se=0.12) and higher fasting insulin (rg=−0.45, se=0.09), impaired beta-cell function (HOMA-B: rg=−0.40, se=0.09), hyperglycaemia (HbA1c: rg=−0.25, se=0.08) and hypertriglyceridemia (rg=−0.17, se=0.04). The gene discussed is INS; the disease is type 2 diabetes mellitus.