In the PA combined sample, as well as genetic correlations with fasting insulin (rg=−0.31, se=0.07), insulin resistance (rg=−0.29, se=0.07) and triglycerides (rg=−0.20, se=0.04), we observed a positive correlation with HDL cholesterol (rg=0.28, se=0.04) and a direct negative correlation with T2D (rg=−0.23, se=0.05). Here, INS is linked to type 2 diabetes mellitus.