CRF-slope functional genes were enriched in GWAS gene sets for the thrombosis and atherosclerosis risk factor PAI-1 (plasminogen activator inhibitor-1: FDR-adjusted p=5.0 × 10-6), heart rate response to exercise and recovery (FDR-adjusted p=1.2 × 10-5) and resting heart rate (FDR-adjusted p=1.4 × 10-3). This evidence concerns the gene SERPINE1 and Venous thrombosis.