Conversely, in the instance of the Bcl-2 and Bcl-xL anti-apoptotic proteins, their genetically deregulated-over-expression can give rise to similar malignancies, such as B-cell lymphoma, prostate cancer, non-small cell lung cancer, Acute lymphoblastic leukaemia and breast cancer [9–12]. Here, BCL2L1 is linked to acute lymphoblastic leukemia.