TP53 and hepatocellular carcinoma: Mechanistically, Gossypol can reduce cellular viability upon p53 activation, as seen in LAPC4, PC-3, and DU-145 prostate cancer (PC) cells [171], through ER stress and autophagy in hepatocellular carcinoma (HCC) cells [172], and oxidative stress, as seen in ovarian and MM cells [166, 173].