Through structure-based design, other ABT-737-derived SMIs targeting Bcl-2 and Bcl-xL, have also arisen in the form of BM-957 and BM-1197, which showed improved solubility, pharmokinetic properties and tumor regression capabilities [298, 299], as single therapeutics against AML [300]. The gene discussed is BCL2L1; the disease is acute myeloid leukemia.