BCL2 and hematologic disorder: Another promising BH3-mimetic, specific for all Bcl-2 proteins includes the rationally-designed and prodiginine-related Obatoclax, which binds the mitochondrially-associated Bcl-2 protein and all pro-survival Bcl-2 proteins with a Ki of 220 nM [61, 190], outlining its suitability for the treatment of hematological malignancies and solid tumors [191, 192].