As a protein highly expressed in a number of B-cell lymphomas [83, 84], Bcl-2 is expressed in Chronic lymphocytic leukaemia (CLL) [85], Mantle cell lymphoma (MCL) [85–87], Multiple myeloma (t11;14) (MM) [88] or solid tumors [83], and (in a similar manner to Mcl1 expression) is critical for cell survival [89]. This evidence concerns the gene MCL1 and plasma cell myeloma.