To test this hypothesis, we ectopically modified exosomes derived from NSCLC cells by the transfection of circUSP7 shRNA and circUSP7 cDNA together with miR-934 into CD8+ T cells to evaluate the mechanism by which circUSP7 regulates miR-934 (Additional File 2: Supplementary Fig. 6a and 6b). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.