To verify this hypothesis, we detected the secretion of TNF-α, IFN-γ, Granzyme-B, and perforin from CD8+ T cells after coculturing CD8+ T cells with exosomes derived from NSCLC cells (Additional File 2: Supplementary Fig. 6c and 6d). The gene discussed is CD8A; the disease is non-small cell lung carcinoma.