The age, pulse pressure difference, proportion of male patients, hypertension, diabetes, previous ischemic stroke, fasting plasma glucose (FPG), HbA1c, creatinine, UA, LDL-C, and Lp-PLA2 were significantly higher in the CSVD group than in the control group (P < 0.05). This evidence concerns the gene PLA2G7 and Hypertension.