The main findings of this study were as follows: 1) even after adjustments for multiple confounding factors, including age, hypertension and previous ischemic stroke at baseline, higher baseline serum LDL-C3 levels were associated with an increased risk of CSVD; and 2) LDL-C3 and LDL-C4 can predict CSVD risk. This evidence concerns the gene C3 and hypertensive disorder.