MBP and Friedreich ataxia: However, there was evidence of a severe reduction in tissue volume and immunoreactivity with a mouse monoclonal anti‐myelin basic protein (MBP) antibody (clone MBP101; ab62631, Abcam, Cambridge, UK; 1:1000) in multiple ascending and descending pathways in the cervical, thoracic, and lumbar segments, including the spinocerebellar tracts and dorsal columns as well as the anterior and lateral corticospinal tracts, in a pattern very similar to those in Friedreich's ataxia (Fig. 3A, B).20