TCF7L2 and cardiac hypertrophy: In the case of TCF7L2, it is found to be involved in cardiac hypertrophy through the Wnt/β-catenin signaling pathway, where it modulates the chromatin environment and regulates the expression of the slow Myh7 (MyHC-1) and the Wnt/β-catenin target, the Myc gene [97].