Human subjects with RORC knockout have been identified and do not exhibit signs of lymphoma [39], however, given our observations and additional reports of RORγt inhibition-induced thymocyte apoptosis in rodents & non-human primates (unpublished results: Bristol Myers Squibb (Haggerty et al. Society of Toxicology conference, 2020) and Genentech (Zbieg et al. Federation of Clinical Immunology Societies conference, 2018) the question remains whether the susceptibility to thymic lymphomas is a rodent-specific phenomenon and whether this presents a significant safety liability in human. The gene discussed is RORC; the disease is lymphoma.