B6 and CAST mice differ in their sensitivity to genotoxic damage induced by 1,3-butadiene, which induces strain-dependent epigenetic and transcriptomic changes in liver, lung and kidney [90,91]; however, differences in hepatocellular carcinoma between mouse strains [92,93] have not been determined for B6 vs CAST mice. Here, CAST is linked to hepatocellular carcinoma.