Remarkably, these findings are in contrast with evidence in type 2 diabetes and obesity, where several defects in insulin signalling, insulin‐stimulated glucose metabolism and an impairment of lipid oxidation, ATP synthesis and OXPHOS have been described to be conserved in human primary myotubes (Gaster et al. 2002, Minet & Gaster 2010, Boyle et al. 2012, Kase et al. 2015). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.