LGR5 and colon carcinoma: The search for activators of NF-κB signaling in the SI will thus continue in the future, but Tnfrsf19 is a potential candidate as it is expressed in SI crypts, is regulated by Wnt in Lgr5-positive CBCs and appears to modulate Wnt signaling in human colon carcinoma cell lines (Fafilek et al., 2013).