These Treg cells in Cd300afl/fl;ItgaxCre mice showed higher expression of Ki67 and CTLA-4 than did Cd300afl/fl mice, although the expressions of CD25, GITR, and BCL2 on tumor-infiltrating Treg cells were comparable between two genotypes of mice (Figure 2D and E, Figure 2—figure supplement 1). The gene discussed is TNFRSF18; the disease is neoplasm.