HAVCR2 and neoplasm: Moreover, the number of CD8+ T cells expressing both PD-1 and TIM-3 and those expressing CTLA-4 were significantly increased in Cd300afl/fl;ItgaxCre mice compared to Cd300afl/fl mice (Figure 2J and K), suggesting that tumor-infiltrating CD8+ T cells display more exhausted state in Cd300afl/fl;ItgaxCre mice than in Cd300afl/fl mice (Sawant et al., 2019).