Moreover, administration of a neutralizing anti-IFN-β antibody showed reduced tumor volume in Cd300afl/fl;ItgaxCre mice to a comparable level of that in Cd300afl/fl mice (Figure 4B), suggesting that IFN-β augmented Treg cell proliferation or survival and promoted tumor progression in Cd300afl/fl;ItgaxCre mice. This evidence concerns the gene IFNB1 and neoplasm.