Although high levels of IL-1β have been reported in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob Disease [24,25] and in the brains of mice inoculated with PrPSc [26–29], others researches have shown that there was no significant difference in IL-1β levels in the brain of terminally ill rats inoculated with RML6 prions[27]. Here, IL1B is linked to Creutzfeldt Jacob disease.