However, when viewed from the perspective of prion disease, TREM2 did not show a contribution to its pathogenesis: there were no significant differences in the disease incubation time or prion titres between the TREM2−/−, TREM2−/+ and TREM2+/+ mice groups, after intracerebral inoculation of Rocky Mountain Laboratories PrPSc strain (RML6). This evidence concerns the gene TREM2 and prion disease.