The higher level of KLRG1+ NK cells found in feralized mice is similar to our previous findings in feralized co-housed mice.34 IFNγ-mediated responses are important in anti-tumor immunity and have been positively associated with survival in CRC,60 and the increased IFNγ response to stimuli in CD8+ T-cells in the feralized mice is also similar to our previous findings in feralized co-housed and feral mice.34 While these findings add consistency to the observed impact by feralization on immunity, more elaborate studies are needed to conclude about causal relationships with CRC protection. This evidence concerns the gene IFNG and colorectal carcinoma.