KLRG1 and colorectal carcinoma: The higher level of KLRG1+ NK cells found in feralized mice is similar to our previous findings in feralized co-housed mice.34 IFNγ-mediated responses are important in anti-tumor immunity and have been positively associated with survival in CRC,60 and the increased IFNγ response to stimuli in CD8+ T-cells in the feralized mice is also similar to our previous findings in feralized co-housed and feral mice.34 While these findings add consistency to the observed impact by feralization on immunity, more elaborate studies are needed to conclude about causal relationships with CRC protection.