APC and colorectal carcinoma: Apc Min/+ mice harbor a mutant allele of the adenomatous polyposis coli (Apc) gene and spontaneously develop adenomatous polyps.18,19 CRC can also be induced chemically by e.g. a combinatory treatment of the pro-carcinogen azoxymethane (AOM) and the inflammatory agent dextran sodium sulfate (DSS).