Normoglycemic conditionswere restored for about 2 weeks based on the solo-controlled degradationof the INS and the consequent sustained release of molecular insulin.Furthermore, mice implanted with 10H INS-μPL successfully regainglycemic control following the ip administration of a glucose bolus.In summary, these data show the potential of 10H INS-μPL asa promising platform for the treatment of T1DM with high and durableefficacy. Here, INS is linked to type 1 diabetes mellitus.