The current standardof care requires multiple, daily injections of insulin and accuratemonitoring of blood glucose levels (BGLs); in some cases, this resultsin diminished patient compliance and increased risk of hypoglycemia.Herein, we engineered hierarchically structured particles comprisinga poly(lactic-co-glycolic) acid (PLGA) prismaticmatrix, with a 20 × 20 μm base, encapsulating 200 nm insulingranules. Here, INS is linked to Hypoglycemia.