Therefore, the role of S1P is not only beneficial for T2DM, especially in the activation of S1PR1 and S1PR2; it may destroy lipogenesis and promote the secretion of cytokines, thereby inhibiting the differentiation of fat cells and insulin signal transduction, inhibiting the proliferation of β cells and inducing their apoptosis. This evidence concerns the gene S1PR1 and type 2 diabetes mellitus.