It has been stated that the increased level of insulin, which is common in type 2 DM due to insulin resistance, causes leptin overproduction, which in turn, increases leptin concentration, is related to the risk of incidence and progression of endometrial and ovarian cancers (Doucet et al., 2000; Ma et al., 2013; Jin et al., 2016). The gene discussed is LEP; the disease is Insulin resistance.