Leptin has been shown to contribute to metastatic advancement of epithelial ovarian cancer by assisting cell migration and tissue invasion by binding to OB-Rb mediated via JAK/STAT3, MAPK, AKT, mTOR, RhoA/ ROCK, and MYPT1 signaling pathways (Wu et al., 2012). The gene discussed is STAT3; the disease is ovarian carcinoma.