Most notably, increased expression of several drusen associated proteins known to be strongly linked to the progression of AMD was observed in chronic oxidative stress conditions in ipRPE cells (ApoE, VTN, C3 and VIN) and ipRPE‐EVs (ApoE, VTN, VIN and CLU) (Figure 7t and S7). This evidence concerns the gene LINC01191 and age-related macular degeneration.