C3 and age-related macular degeneration: Excitingly, some of the key proteins known to contribute to drusen formation during AMD (Crabb et al., 2002; Wang et al., 2010) such as apolipoprotein E (ApoE), apolipoprotein A‐2 (APOA2), clusterin (CLU), vitronectin (VTN), vinculin (VIN), complement 3 (C3) and alpha‐crystallin B (CRYAB) were also found in our ipRPE‐EVs (Figure 6i).