Genetic variants at the Regulators of Complement Activation (RCA) locus on chromosome 1, which contains the CFH gene, contributes to AMD risk [9–11], in addition to the CFI gene region on chromosome 4 [12–14], and the SERPING1 gene that encodes the C1 inhibitor [15, 16]. Here, SERPING1 is linked to age-related macular degeneration.