Genetic variants at the Regulators of Complement Activation (RCA) locus on chromosome 1, which contains the CFH gene, contributes to AMD risk [9–11], in addition to the CFI gene region on chromosome 4 [12–14], and the SERPING1 gene that encodes the C1 inhibitor [15, 16]. This evidence concerns the gene CFI and age-related macular degeneration.