BRCA1 and triple-negative breast carcinoma: MDA-MB-436, a triple-negative breast cancer cell line model harbouring a loss of function mutation in BRCA1, also exhibited EX527 and salermide sensitivity (BRCA1:c.5396+1G>A, Supplementary Fig. 2a, b, SF50 = 18 μM and SF50 = 12 μM, respectively), suggesting that this effect was not private to SUM149 or DLD1 isogenic models.