We found that reduction of Sp4 expression in Sp4 hypomorphic mice causes age-dependent hippocampal vacuolization, reduced hippocampal LTP, and many behavioral abnormalities related to schizophrenia such as deficits in prepulse inhibition, deficient learning and memory, hypersensitivity to NMDAR antagonists, etc. [4, 6–8]. The gene discussed is SP4; the disease is schizophrenia.