The lncRNA ORAOV1-B is a newly discovered AS variant of the ORAOV1 gene, which activates the tumour necrosis factor-κB (TNF-κB)/TNFα loop by interacting with heat-shock protein 90 (HSP90), and then induces the EMT mechanism to promote the invasion and metastasis of oral squamous cell carcinoma [31] (Fig. 1c). Here, LTO1 is linked to oral cavity squamous cell carcinoma.