The interaction between TPM1-AS and RBM4 hinders the binding of RBM4 to TPM1 pre-mRNA and inhibits the inclusion of endogenous exon 2a of TPM1, resulting in the specific downregulation of TPM1 variants V2 and V7 in human oesophageal cancer cells, and producing the TPM1 mRNA variants V1, V3, V4 and V5, thereby inhibiting the migration and mitosis of human oesophageal cancer cells [54] (Fig. 4c). Here, TPM1 is linked to carcinoma of esophagus.