MAPK8 and cyclic hematopoiesis: RT-PCR showed that the mRNA expression levels of SYK, P38, JNK, PI3K, and ERK were significantly higher in the LGBLEL compared with the orbital CH group (P = 0.0066; P = 0.0002; P = 0.0003; P < 0.0001; P < 0.0001, respectively) (Fig. 3).