MSTN and peripheral arterial disease: In patients with peripheral artery disease, high flavanol cocoa supplementation for 3 months led to a significant increase in the 6-min walk test while increasing calf perfusion and capillarity26 and in Becker muscular dystrophy patients, treatment with Epi (50 mg BID for 2 months) led to increases in quadriceps and plasma follistatin levels while myostatin decreased14.