The results showed that there was no significant difference in Notch3 and Jagged1 between mild patients and patients without liver fibrosis (P > 0.05), but the expression of Notch3 and Jagged1 in moderate and severe patients was significantly higher than that in patients without liver fibrosis (P < 0.05) (Fig. 2B–D). The gene discussed is JAG1; the disease is Hepatic fibrosis.