Zheng et al. found that Notch3 may be involved in liver fibrosis by regulating the activation of hepatic stellate cells (HSCs); after downregulation of Notch3 by lentivirus transfected cells, Notch3, Jagged1, Hes1 and α-SMA were downregulated, and in mice with in vivo inhibition of Notch3, this downregulation was accompanied by improved liver fibrosis22. The gene discussed is HES1; the disease is Hepatic fibrosis.