CCNE1 and acute myeloid leukemia: Many of the gene products deregulated in cancers, such as MYC, TP53, CCNE, KRAS, HSP90, ESR1, Cyclin E, STAT3, NOTCH, AML/ETO, and mTOR, are CCT client proteins [4–6], which advise an indispensable role for its contribution to malignant transformation.