In addition, most of the RelA + , Caspase-1+ or IL-1β+ synoviocytes might co-localize with F4/80+ macrophages, suggesting the majority of cells carrying activated NF-κB/NLRP3 signaling in TNFTG RA synovium may be macrophages. The gene discussed is NLRP3; the disease is rheumatoid arthritis.