To explore the role of NLRP3 in RA pathogenesis, we deleted NLRP3 gene in TNFTG RA mice to generate NLRP3KO/TNFTG mice, their joint phenotypes were compared with those of NLRP3KO, TNFTG, and WT mice. This evidence concerns the gene NLRP3 and rheumatoid arthritis.