It would be beneficial to generate myeloid-specific NLRP3-overexpression or knockout mice by crossing NLRP3TG mice or NLRP3-floxed mice with LysM-cre or CX3CR1-cre mice and then inducing RA by injecting mice with type II collagen in the absence and presence of AAV-miR-30a administration. Here, NLRP3 is linked to rheumatoid arthritis.