Interestingly, there is a growing interest in the maternally imprinted DLK1-DIO3 region on chromosome 14q32 because ~53 miRNAs are embedded in two adjacent clusters, many of which have been reported to be deregulated in various cancers, such as, APL [28], melanoma [29], and lung adenocarcinomas [30]. This evidence concerns the gene DIO3 and cancer.