Overexpression of the 14q32 cluster miRNAs has been associated with the CCCTC-binding factor (CTCF)-mediated regulation of the maternally expressed gene 3 differentially methylated region (MEG3-DMR) [31] or global genomic hypomethylation of 14q32 locus as reported in various cancers [32], including CLL [33]. This evidence concerns the gene CTCF and cancer.