PTEN and B-cell chronic lymphocytic leukemia: Additionally, in vitro acalabrutinib treatment of naïve (#CLL4, #CLL5) vs treatment-relapsed (#CLL6, #CLL7) CLL patients revealed significant increase in pten mRNA levels in #CLL4 (2.9-fold) and #CLL5 (3.2-fold) in contrast to #CLL6 and #CLL7 (Fig. 3d).