The nontrivial interaction of these inputs predicted by this model is different in comparison to many established and current candidate biomarker studies (which focus on linear immunotherapy responses to just one of these markers, e.g., PD-L1 expression [Carbognin et al., 2015]), perhaps providing a plausible explanation why single biomarkers sometimes provide inconsistent predictions across multiple cancer types (Carbognin et al., 2015). The gene discussed is CD274; the disease is cancer.