DAGL, MAGL, ABHD6, NAPE-PLD, FAAH, CB1, and CB2 expression and localization were determined using immunohistochemistry of the PAG, a nucleus implicated in the descending pain modulatory pathways, using the occipital cortex (V1M), a site often associated with the induction of cortical spreading depression events linked to migraine aura, for comparison. The gene discussed is CNR1; the disease is migraine disorder.